To evaluate organ-specific expression enrichment, we calculated for each miRNA an organ enrichment index (OEI), which is analogous to the tissue specificity index (TSI) ‘tau’ for mRNAs and has been previously used for miRNAs. The OEI varies from 0 to 1, with OEI close to 0 correspondings to miRNAs expressed in many or most organs at similar levels (i.e. ‘housekeeping’ miRNAs), and OEI close to 1 corresponding to miRNAs expressed in a specific organ (i.e. organ-enriched miRNAs). The OEI for miRNA j is calculated as:
where N corresponds to the total number of organs studied and xi,j is the expression of miRNA j in organ i normalized
Paper: 10.1038/s41598-019-40361-8
GitHub: https://github.com/uoregon-postlethwait/prost
readthedocs: https://prost.readthedocs.io/en/latest/index.html#
Interesting feature:
Organ-Enrichment Index
To evaluate organ-specific expression enrichment, we calculated for each miRNA an organ enrichment index (OEI), which is analogous to the tissue specificity index (TSI) ‘tau’ for mRNAs and has been previously used for miRNAs. The OEI varies from 0 to 1, with OEI close to 0 correspondings to miRNAs expressed in many or most organs at similar levels (i.e. ‘housekeeping’ miRNAs), and OEI close to 1 corresponding to miRNAs expressed in a specific organ (i.e. organ-enriched miRNAs). The OEI for miRNA j is calculated as:
where N corresponds to the total number of organs studied and xi,j is the expression of miRNA j in organ i normalized