AD in cells

[penglbio]

对于之前的提问，感谢您的快速回答，这里还有另外一个问题：我想知道的是，为什么会在单个细胞中鉴定ＳＮＰ会有等位基因频率一说呢，不应该是在一个群体中鉴定ＳＮＰ的时候才存在等位基因频率？　对于一个基因来说，我以为突变了之后，所有的ＲＮＡ转录出来的序列都应该是在该位置有突变。　还是说这个ＡＤ有其他的含义呢？

For the previous question, thank you for your quick answer. Here is another question: I would like to know why there is allele frequency in the identification of SNP in a single cell. It should not be the allele frequency when identifying SNP in a population? For a gene, I think that after mutation, all RNA transcripts should have mutations at this location. Or does this ＡＤ　have other meanings?

[huangyh09]

It is heterozygous genotype, and there are often imbalance in the expression of the two alleles, which refers to the "allele frequency" and has different meaning in population genomics.