Clarification on demuxing with vcf

single-cell-genetics / cellsnp-lite

Efficient genotyping bi-allelic SNPs on single cells

https://cellsnp-lite.readthedocs.io

Apache License 2.0

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Closed cnk113 closed 3 years ago

cnk113 commented 3 years ago

Hello,

I'm trying to demux pooled samples of multiple individuals, I have a vcf file for each individual, but it seems the vcf input is for a single file?

Best, Chang

huangyh09 commented 3 years ago

Yes, you can use bcftools merge to make a combined vcf for all donors.

Yuanhua