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smithlabcode / ribotricer

A tool for accurately detecting actively translating ORFs from Ribo-seq data
http://doi.org/djv4
GNU General Public License v3.0
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Option to include multimapping reads? #125

Closed PVlasov93 closed 2 years ago

PVlasov93 commented 2 years ago

If I understand correctly, the program's default setting for handling multi-mapped reads is to disregard them entirely and only calculate translation behavior from single-mapped reads. Is there a setting that changes this?

saketkc commented 2 years ago

We currently do not support multimapping reads. I am also not sure how they should be handled given the requirement of having base-pair level resolution. Feel free to reopen if you have any follow up questions.