fix: allow somatic-normal mutations above VAF 0.5

snakemake-workflows / dna-seq-mtb

A flavor of https://github.com/snakemake-workflows/dna-seq-varlociraptor preconfigured for molecular tumor boards

MIT License

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fix: allow somatic-normal mutations above VAF 0.5 #8

Closed johanneskoester closed 1 year ago

johanneskoester commented 2 years ago

This fixes an issue with VAFs of e.g. 0.9 in the normal, which would have otherwise erroneously driven the system towards calling an LOH with VAF 0.5 in the normal if the difference of 0.1 in the VAF cannot be explained by MAPQ.