snijderlab / stitch

Template-based assembly of proteomics short reads for de novo antibody sequencing and repertoire profiling
MIT License
22 stars 3 forks source link

Template Refine #208

Open douweschulte opened 1 year ago

douweschulte commented 1 year ago

In discussion the idea arose to add an extra step after template matching which again matches all reads to the template, this should improve the final consensus sequence. Also detecting how many more reads could be placed or how much higher the score gets could be a very promising means of selecting templates for recombination if that is done afterwards.