soedinglab / hh-suite

Remote protein homology detection suite.
https://bmcbioinformatics.biomedcentral.com/articles/10.1186/s12859-019-3019-7
GNU General Public License v3.0
515 stars 128 forks source link

Does the template searching result contain query sequence's structure or not? #354

Open psp3dcg opened 11 months ago

psp3dcg commented 11 months ago

Context

If the template database (such as pdb100) contains the structure of the query sequence, will "hhsearch" return the structure information of the query sequence as a part of template? If so, how to remove the structural information of the query sequence itself from the template? Thank U~

Your Environment

Include as many relevant details about the environment you experienced the issue in.

psp3dcg commented 11 months ago

I usually use MSA generated by hhblits as input for hhsearch.

milot-mirdita commented 6 months ago

We add secondary structure information to the PDB70. You can disable secondary structure information by passing -ssm 0 to HHblits/HHsearch.

milot-mirdita commented 6 months ago

The PDB100 I created for ColabFold does not contain secondary structure information.