soedinglab / hh-suite

Remote protein homology detection suite.
https://bmcbioinformatics.biomedcentral.com/articles/10.1186/s12859-019-3019-7
GNU General Public License v3.0
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Does the template searching result contain query sequence's structure or not? #354

Open psp3dcg opened 1 year ago

psp3dcg commented 1 year ago

Context

If the template database (such as pdb100) contains the structure of the query sequence, will "hhsearch" return the structure information of the query sequence as a part of template? If so, how to remove the structural information of the query sequence itself from the template? Thank U~

Your Environment

Include as many relevant details about the environment you experienced the issue in.

psp3dcg commented 1 year ago

I usually use MSA generated by hhblits as input for hhsearch.

milot-mirdita commented 11 months ago

We add secondary structure information to the PDB70. You can disable secondary structure information by passing -ssm 0 to HHblits/HHsearch.

milot-mirdita commented 11 months ago

The PDB100 I created for ColabFold does not contain secondary structure information.