Closed bgyori closed 7 years ago
This could be an issue in the EKB agent or it could be an issue in INDRA's TRIPS processor. Either way, this is incorrect:
(REQUEST :CONTENT (BUILD-MODEL :DESCRIPTION "<ekb timestamp=\"20170829T123202\"> <EVENT id=\"V81361\"> <type>ONT::BIND</type> <force>ONT::TRUE</force> <arg id=\"V81353\" role=\":AFFECTED\"/> <arg id=\"V81407\" role=\":AFFECTED1\"/> </EVENT> <TERM id=\"V81353\" dbid=\"UP:P79800|UP:Q9YH38|HGNC:6407|XFAM:PF00071|UP:Q05147|UP:O42277|NCIT:C17383|UP:Q5EFX7|UP:P01116|NCIT:C16766\"> <type>ONT::GENE-PROTEIN</type> <name>KRAS</name> <features> <inevent id=\"V81361\"/> </features> <drum-terms> <drum-term name=\"KRAS proto-oncogene, GTPase\" matched-name=\"KRAS\" match-score=\"1.0\" dbid=\"HGNC:6407\"> <types> <type>ONT::GENE</type> </types> <xrefs> <xref dbid=\"UP:P01116\"/> </xrefs> </drum-term> <drum-term dbid=\"NCIT:C16766\" matched-name=\"KRAS\" name=\"oncogene K-ras\" match-score=\"0.82857\"> <types> <type>ONT::GENE</type> </types> </drum-term> <drum-term dbid=\"NCIT:C17383\" matched-name=\"KRAS\" name=\"p21 K-ras protein\" match-score=\"0.82857\"> <types> <type>ONT::PROTEIN</type> </types> </drum-term> <drum-term match-score=\"0.6528\" matched-name=\"K-ras\" name=\"GTPase KRas\" dbid=\"UP:Q9YH38\"> <types> <type>ONT::PROTEIN</type> </types> <xrefs> <xref dbid=\"XFAM:PF00071\"/> </xrefs> </drum-term> <drum-term name=\"GTPase KRas\" matched-name=\"K-ras\" match-score=\"0.6528\" dbid=\"UP:Q5EFX7\"> <types> <type>ONT::PROTEIN</type> </types> <xrefs> <xref dbid=\"XFAM:PF00071\"/> </xrefs> </drum-term> <drum-term dbid=\"UP:P79800\" name=\"GTPase KRas\" matched-name=\"K-ras\" match-score=\"0.6528\"> <types> <type>ONT::PROTEIN</type> </types> <xrefs> <xref dbid=\"XFAM:PF00071\"/> </xrefs> </drum-term> <drum-term match-score=\"0.6528\" matched-name=\"K-ras\" name=\"GTPase KRas\" dbid=\"UP:O42277\"> <types> <type>ONT::PROTEIN</type> </types> <xrefs> <xref dbid=\"XFAM:PF00071\"/> </xrefs> </drum-term> <drum-term dbid=\"UP:Q05147\" match-score=\"0.6528\" matched-name=\"K-ras\" name=\"GTPase KRas\"> <types> <type>ONT::PROTEIN</type> </types> <xrefs> <xref dbid=\"XFAM:PF00071\"/> </xrefs> </drum-term> </drum-terms> </TERM> <TERM id=\"V81407\" dbid=\"CHEBI:37565|CHEBI:15996\"> <type>ONT::MOLECULE</type> <name>GTP</name> <drum-terms> <drum-term match-score=\"1.0\" name=\"GTP\" matched-name=\"GTP\" dbid=\"CHEBI:15996\"> <types> <type>ONT::CHEMICAL</type> <type>ONT::MOLECULE</type> </types> </drum-term> <drum-term match-score=\"0.6387\" matched-name=\"gtp\" name=\"GTP(4-)\" dbid=\"CHEBI:37565\"> <types> <type>ONT::CHEMICAL</type> <type>ONT::MOLECULE</type> </types> </drum-term> </drum-terms> </TERM> <EVENT id=\"V81412\"> <type>ONT::PHOSPHORYLATION</type> <force>ONT::TRUE</force> <arg role=\":AGENT\" id=\"V81353\"/> <arg id=\"V81417\" role=\":AFFECTED\"/> <site id=\"V81464\"/> <drum-terms> <drum-term dbid=\"GO:0006468\" match-score=\"1.0\" name=\"protein phosphorylation\" matched-name=\"protein phosphorylation\"> <types> <type>ONT::POST-TRANSLATIONAL-MODIFICATION</type> </types> </drum-term> </drum-terms> </EVENT> <TERM id=\"V81417\" dbid=\"NCIT:C17476|HGNC:1097|NCIT:C51194|UP:P15056\"> <type>ONT::GENE-PROTEIN</type> <name>BRAF</name> <drum-terms> <drum-term match-score=\"1.0\" matched-name=\"BRAF\" name=\"B-Raf proto-oncogene, serine/threonine kinase\" dbid=\"HGNC:1097\"> <types> <type>ONT::GENE</type> </types> <xrefs> <xref dbid=\"UP:P15056\"/> </xrefs> </drum-term> <drum-term dbid=\"NCIT:C51194\" match-score=\"1.0\" matched-name=\"BRAF\" name=\"BRAF\"> <types> <type>ONT::GENE</type> </types> </drum-term> <drum-term name=\"B-RAF protein kinase\" matched-name=\"BRAF\" match-score=\"0.82857\" dbid=\"NCIT:C17476\"> <types> <type>ONT::PROTEIN</type> </types> </drum-term> </drum-terms> </TERM> <TERM id=\"V81464\"> <type>ONT::MOLECULAR-SITE</type> <name>T-373</name> <features> <site> <name>Threonine</name> <code>T</code> <pos>373</pos> </site> </features> </TERM> </ekb>") :REPLY-WITH BUILD-MODEL-854 :sender BA) From MRA: (reply :content (SUCCESS :model-id 8 :model "[{\"type\": \"Complex\", \"members\": [{\"name\": \"KRAS\", \"db_refs\": {\"TEXT\": \"KRAS\", \"HGNC\": \"6407\", \"UP\": \"P01116\", \"NCIT\": \"C17383\"}}, {\"name\": \"GTP\", \"db_refs\": {\"TEXT\": \"GTP\", \"CHEBI\": \"CHEBI:15996\"}}], \"evidence\": [{\"source_api\": \"trips\"}], \"id\": \"77e4e859-767d-433a-bc06-c54988264e1f\", \"sbo_definition\": \"http://identifiers.org/sbo/SBO:0000526\"}, {\"type\": \"Phosphorylation\", \"enz\": {\"name\": \"KRAS\", \"db_refs\": {\"TEXT\": \"KRAS\", \"HGNC\": \"6407\", \"UP\": \"P01116\", \"NCIT\": \"C17383\"}, \"sbo_definition\": \"http://identifiers.org/sbo/SBO:0000460\"}, \"sub\": {\"name\": \"BRAF\", \"db_refs\": {\"TEXT\": \"BRAF\", \"HGNC\": \"1097\", \"UP\": \"P15056\", \"NCIT\": \"C17476\"}, \"sbo_definition\": \"http://identifiers.org/sbo/SBO:0000015\"}, \"residue\": \"T\", \"position\": \"373\", \"evidence\": [{\"source_api\": \"trips\"}], \"id\": \"63a1a78e-89fa-499f-bbfe-e66d0c55619d\", \"sbo_definition\": \"http://identifiers.org/sbo/SBO:0000216\"}]" :diagram "/home/bmg16/src/cwc-integ/hms/bioagents/model8_rxn.png") :receiver BA :in-reply-to BUILD-MODEL-854 :sender MRA)
This is fixed via INDRA but should be tested for regressions.
Done in 1c1bdb67aa21a4e51844107c4ab9053e82fde897
This could be an issue in the EKB agent or it could be an issue in INDRA's TRIPS processor. Either way, this is incorrect: