How to properly remove all distance constraints in CellChat for spatial imaging data

[jessielam415]

I am working with 10x visium spatial transcriptomics data. When reading the function documentation for computeCommunProb, I noticed that there are a few parameters that seem to affect whether distance affects the communication probability, namely distance.use, interaction.length, and scale.distance. How do I set these parameters such that distance does not play a role in the prediction of communication probability? I am working with data where there would be anticipated long-distance cell-cell communication events, so I do not want long distances to affect calculated communication probability.

[sqjin]

@jessielam415 One option is to set a larger interaction length so that it will not affect whether the two cell group can communicate. Another option is to treat the data as scRNA-seq data.