Previous growth rate knockout data was generated using the RECON1 metabolic reconstruction and used quartiles to delineate between up- and downregulation. This pass uses new method to generate single-cell profiles in RECON1 and iHUMAN.
Tasks:
[x] Debug Great Lakes software to perform constraint-based metabolic modeling
[x] Re-compute metabolic fluxes in RECON1
[x] Compute metabolic fluxes in iHUMAN
[x] Re-compute growth rates from gene and reaction knockout in RECON1
[x] Compute growth rates from gene knockout in iHUMAN
Previous growth rate knockout data was generated using the RECON1 metabolic reconstruction and used quartiles to delineate between up- and downregulation. This pass uses new method to generate single-cell profiles in RECON1 and iHUMAN.
Tasks: