statgen / METAL

Meta-analysis of genomewide association scans
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Wrong formula in the manuscript? #13

Open GillianGrayson opened 3 years ago

GillianGrayson commented 3 years ago

Hello! If I understood correctly there is a problem in the last formula from this section of the manuscript: image In this part: image There should be the "minus modulus" in the argument of Ф. Not the "modulus minus".

Imagine the situation when you have all negative directions of Delta_i, then all your Z_i values will be positive as like as Overall Z-score. For example Z = 5. Then P-value will be 2 * 0.9... > 1. P-value is the probability - it cannot be more than 1.

Please, correct me Do you use the correct formula in the code?