statgen / METAL

Meta-analysis of genomewide association scans
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IS MINWEIGHT necessary? #20

Open isabelleboothman opened 2 years ago

isabelleboothman commented 2 years ago

Hi, I just have a question about MINWEIGHT, I am running a meta-analysis between 3 studies all that have a small sample size and an imbalance between cases/controls. I have calculated N_eff for each of the studies and have that column as the Weight.

I am currently including MINWEIGHT as 90% of the sum of all the N-effs for the three studies, is this correct? Do I need to include MINWEIGHT in this study?

Thanks, Isabelle