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stephenslab / mashr

An R package for multivariate adaptive shrinkage.
https://stephenslab.github.io/mashr
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Local false sign rate of 0? #92

Closed ghost closed 3 years ago

ghost commented 3 years ago

Hi,

Should I be suspicious of local false sign rates of zero? I noticed some of these when getting Inf values from -log10(lfsr).

Apologies if I've missed some documentation on this.

Thank you!

pcarbo commented 3 years ago

No, LFSRs of zero are (numerically) indistinguishable from very small LFSRs. This is similar to the situation for p-value calculations, where it can be difficult to distinguish between a p-value of zero and a very small p-value.

ghost commented 3 years ago

Thanks!