Sometimes a variant is called in a sample, but similar variants are also present in the control sample for the run. Consider one or more of the following:
for every sample, look for similar variants in control sample
for IonTorrent VCF variant entries that have multiple called variants at a single location, develop system of flagging these variants as possible artifacts
The default ~500 height IGV snapshots might not be tall enough to see the presence of indels and other artifacts throughout the reads at a locus, consider generating extra long ~5000 height snapshots for these variants; link to report?
need to develop system for quickly & easily removing these from the report & summary tables upon manual review and feedback from clinicians
Sometimes a variant is called in a sample, but similar variants are also present in the control sample for the run. Consider one or more of the following: