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sys-bio / SBstoat

Parameter optimization using Tellurium
MIT License
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Provide multiple starts for fitting #8

Open joseph-hellerstein opened 3 years ago

joseph-hellerstein commented 3 years ago

Consider multiple starting points for the optimization to have a better chance of discovering the global minimum.

CiaranWelsh commented 3 years ago

One strategy is to use Latin Hypercube Sampling (LHS) to sample the parameters used for input. I've used the pyDOE implementation in the past. Also I remember a conversation with Jens Timmer a few years back who suggested the fitting itself should be done in log space and converted back at the end.