Thank you for this great tool. I wanted to know if I could use metacell in a supervised way. My single-cell RNAseq data also consists of lineage barcodes. What I want to do is to define the cells with certain clones(barcodes) as metacell so that I can define the others (which lack clones) based on that. Is it possible to do that? Instead of identifying the metacell, feed the program with the cell of your choice.
The reason we want to try this is @that usually for such experiments only very few cells end up having clones and it makes it hard to perform differential analysis.
Hi,
Thank you for this great tool. I wanted to know if I could use metacell in a supervised way. My single-cell RNAseq data also consists of lineage barcodes. What I want to do is to define the cells with certain clones(barcodes) as metacell so that I can define the others (which lack clones) based on that. Is it possible to do that? Instead of identifying the metacell, feed the program with the cell of your choice.
The reason we want to try this is @that usually for such experiments only very few cells end up having clones and it makes it hard to perform differential analysis.
Best, Ann