Key difference between single cell hic and normal population hic in terms of building 3D model

tanlongzhi / dip-c

Tools to analyze Dip-C (or other 3C/Hi-C) data

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Key difference between single cell hic and normal population hic in terms of building 3D model #29

Closed kainblue closed 5 years ago

kainblue commented 5 years ago

Hi Longzhi,

I really appreciate all the help you provide. I really like the 3D model you build in the original science paper. Now the biggest question in my mind is can I apply dip-c software on normal population hic? If not, what would be the key hurdle for preventing that happen?

Thanks

tanlongzhi commented 5 years ago

Hi Bo,

Please see my explanation in this thread.

In general, it's much easier to 3D-model single-cell data, because only a single 3D structure exists. However, there're already many papers on 3D-modeling bulk data. Two researchers I personally know are Irene Farabella and Bin Zhang; but there're plenty more working on bulk Hi-C.

kainblue commented 5 years ago

Thank you so much for pointing me to the right direction! I will look into the their work!