tdudgeon / simple-simulate-complex

Simple protein-ligand complex simulation with OpenMM
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How to calculate the binding free energy after the simulation? #4

Closed microbenh closed 3 years ago

tdudgeon commented 3 years ago

You can't directly from that type of simple simulation. You would need to run techniques such as MM-GBSA or MM-PBSA which are more complex to set up and need analysis to generate approximations of binding. I'd like to set up examples for this if anyone would like to contribute.