openNCA computation engine is an R package that provides for generation of pharmacokinetic parameter estimates using non-compartmental (NCA) pharmacokinetic analysis methods.
MIT License
27
stars
5
forks
source link
2020-06-08 Inconsistencies in create_dependency_list #251
A new method was proposed for determining which parameters should be computed (i.e. comp_required) in #159. While testing this method a few inconsistencies were found in create_dependency_list.
Both TAUi and TOLDi are predecessors of TAUi and TOLDi
Suggestion to remove these predecessors from TAUi and TOLDi
Causes infinite recursion with proposed method (#159)
If both of these parameters truly are predecessors for TAUi and TOLDi, removal will not prevent their computation, all dependent parameters that have TAUi as a predecessor also have TOLDi and vice versa
DOF is mentioned as a predecessor despite not being in create_dependency_list
Issue
A new method was proposed for determining which parameters should be computed (i.e.
comp_required) in #159. While testing this method a few inconsistencies were found increate_dependency_list.TAUiandTOLDiare predecessors ofTAUiandTOLDiTAUiandTOLDiTAUiandTOLDi, removal will not prevent their computation, all dependent parameters that haveTAUias a predecessor also haveTOLDiand vice versaDOFis mentioned as a predecessor despite not being increate_dependency_listDOFtoDOFi