search

tensfeldt / openNCA

openNCA computation engine is an R package that provides for generation of pharmacokinetic parameter estimates using non-compartmental (NCA) pharmacokinetic analysis methods.
MIT License
27 stars 5 forks source link

2020-09-11 tc1704_M3SS CMIN is not included at pre-dose/zero concentration for the parameter AUCLAST #268

Closed TomTensfeldt closed 4 years ago

TomTensfeldt commented 4 years ago

Testcase tc1704_M3SS demonstrates with commit cca452d that CMIN is not included as specified in the value of AUCLAST generated for Model 3 Steady State.

The concentration data using actual time post dose (PKATPD) is as follows

SDEID SUBJID PKPTMS PKATPD PKCNCN TOLD TAU
130080925 1 0.5 0.50 347.00 0 168
130080925 1 2.0 2.00 109.00 0 168
130080925 1 8.0 8.00 39.50 0 168
130080925 1 24.0 24.00 16.00 0 168
130080925 1 72.0 70.00 2.91 0 168
130080925 1 120.0 93.25 1.29 0 168
130080925 1 168.0 164.25 1.85 0 168

The results from execution of run_computation are summarized as follows:

SDEID CMIN AUCLAST AUCLAST1 AUCTAU1 CTOLDest1
130080925 1.29 1645.032 1732.104 1736.289 1.29

Note that AUCLAST and AUCLAST1 differ considerably.

The reason for this is that there is no value included at pre-dose/zero time for the AUCLAST result.

All of the information supporting this testcase is stored in the onedrive repository.

jhhughes256 commented 4 years ago

This issue no longer occurs with commit 472a0a2. Output shown below, where AUCLAST and AUCLAST1 no longer differ. This result is also reflected in the HTML reports.

knitr::kable(r[c("SDEID", "CMIN", "AUCLAST", "AUCLAST1", "AUCTAU1", "CTOLDest1")])
SDEID CMIN AUCLAST AUCLAST1 AUCTAU1 CTOLDest1
130080925 1.29 1732.104 1732.104 1736.289 1.29