The Compositional Perturbation Autoencoder (CPA) is a deep generative framework to learn effects of perturbations at the single-cell level. CPA performs OOD predictions of unseen combinations of drugs, learns interpretable embeddings, estimates dose-response curves, and provides uncertainty estimates.
Hi, thanks for your nice work!
I am interested in the results from Figure 2, but I couldn't find the sciplex dataset: sci-Plex samples (n = 290,889) of A549, K562, and MCF7 cell lines.
Could you please let me know how to obtain the preprocessed dataset as described in your code?
adata = sc.read('/home/icb/carlo.dedonno/projects/cpa-reproducibility/datasets/sciplex3_new.h5ad')
adata_old = sc.read('/home/icb/carlo.dedonno/projects/cpa-reproducibility/datasets/sciplex3_old_reproduced.h5ad'
Hi, thanks for your nice work! I am interested in the results from Figure 2, but I couldn't find the sciplex dataset: sci-Plex samples (n = 290,889) of A549, K562, and MCF7 cell lines.
Could you please let me know how to obtain the preprocessed dataset as described in your code? adata = sc.read('/home/icb/carlo.dedonno/projects/cpa-reproducibility/datasets/sciplex3_new.h5ad') adata_old = sc.read('/home/icb/carlo.dedonno/projects/cpa-reproducibility/datasets/sciplex3_old_reproduced.h5ad'
Thank you very much!