This study aims to dissect gene-environment interactions on gene expression and regulation in immune cells using scRNA-seq data from 120 donors being stimulated with 3 pathogens, for 2 different timepoints. More specifically, we identified context- and cell-type-specific eQTLs and co-expression QTLs in PBMCs.
Link to publication: https://www.biorxiv.org/content/10.1101/2021.06.04.447088v1
Title of publication: Single-cell RNA-sequencing reveals widespread personalized, context-specific gene expression regulation in immune cells
First author of publication: Roy Oelen
DOI preprint: 10.1101/2021.06.04.447088
DOI journal:
Download link to any data objects required: https://eqtlgen.org/sc/datasets/1m-scbloodnl-dataset.html https://ega-archive.org/studies/EGAS00001005376
Human
10X genomics
PBMCs
This study aims to dissect gene-environment interactions on gene expression and regulation in immune cells using scRNA-seq data from 120 donors being stimulated with 3 pathogens, for 2 different timepoints. More specifically, we identified context- and cell-type-specific eQTLs and co-expression QTLs in PBMCs.