[CLOSED] inspect regulatory diff connections

thpar / diffany

Diffany is an open-source toolbox for calculating and visualizing differential networks.

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[CLOSED] inspect regulatory diff connections #190

Closed diffany-admin closed 9 years ago

diffany-admin commented 9 years ago

Issue by svlandeg Tue Sep 9 14:20:42 2014

at5g13790 (AGL15) increases_regulation at2g39010 (PIP2E) --> how can this be, when PIP2E is negatively DE and AGL15 is not DE?

diffany-admin commented 9 years ago

Comment by svlandeg Tue Sep 9 14:33:41 2014

Normally, there is repression of PIP2E by AGL15, and this seems to be what's happening indeed. But how to depict this in the network? "increases_regulation" could be misleading and interpreted as "upregulation"

diffany-admin commented 9 years ago

Comment by svlandeg Tue Sep 9 14:36:41 2014

at5g51850 is also negatively DE, but is usually upregulated by AGL15, thus there the differential type is "decrease_regulation"

diffany-admin commented 9 years ago

Comment by svlandeg Wed Sep 10 07:46:13 2014

AGL15 -> PIP2E should indeed be a decrease of regulation