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tianshilu / pMTnet

Deep Learning the T Cell Receptor Binding Specificity of Neoantigen
GNU General Public License v2.0
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Prediction with unknown HLA #12

Closed wu-yc closed 2 years ago

wu-yc commented 2 years ago

Dear Tianshi,

I want to examine the connection between peptides and TCR, but without the related HLA information. Do you have any suggestions?

Thank you so much for your attention and help. Yingcheng

wtwt5237 commented 2 years ago

@wu-yc , theoretically, you can try to input your peptide, your TCR and every possible HLA into pMTnet, and then average over all HLAs (sort of like deriving the marginal distribution). But we haven't tested this approach before, and we are not sure whether it is good or not

wu-yc commented 2 years ago

@wtwt5237 Thanks so much for your helpful instructions.