timothyfrasier
commented
2 years ago Hi Lucia:
I'm afraid that I can't quite follow exactly what you did (i.e., how you set up your analyses, and/or what your analyses were), and how the results are tied to each analysis. Could you please describe them in more detail, and then hopefully I will be able to help.
-Tim
Timothy R. Frasier Coordinator: Forensic Sciences Program Professor: Biology Saint Mary's University 923 Robie Street Halifax, Nova Scotia B3H 3C3 Canada Tel: (902) 491-6382 E-mail: @.*** frasierlab.ca
From: luuciasainz @.> Sent: Monday, July 11, 2022 9:52 AM To: timothyfrasier/related @.> Cc: Subscribed @.***> Subject: [timothyfrasier/related] Relatedness-Fis contradiction (Issue #10)
Hi Timothy,
I run the coancestry analysis for a dataset of 98 individuals and 7400 SNPs. The highest values of relatedness among individuals have been obtained for those belonging to a population with the lowest Fis coefficient. Almost every pairs of individuals of that population have a relatedness value between 0.15 and 0.17 (the maximun value was 0.17). The inbreeding estimates obtained by the function also agree with Fis. I have no idea about the reason of these inconsistent results. I understood that the higher values of inbreeding coefficient, the higher relatedness values would be obtained. Am I doing or understanding something wrong? Maybe I am ignoring some mathematical detail.
Thank you so much!
Lucía
— Reply to this email directly, view it on GitHubhttps://can01.safelinks.protection.outlook.com/?url=https%3A%2F%2Fgithub.com%2Ftimothyfrasier%2Frelated%2Fissues%2F10&data=05%7C01%7Ctimothy.frasier%40smu.ca%7C83c1dbedcdda40b8161108da633c2988%7C060b02ae57754360abbae2e29cca6627%7C1%7C0%7C637931407282537665%7CUnknown%7CTWFpbGZsb3d8eyJWIjoiMC4wLjAwMDAiLCJQIjoiV2luMzIiLCJBTiI6Ik1haWwiLCJXVCI6Mn0%3D%7C3000%7C%7C%7C&sdata=Un3Mhz8SxDmTcwgx4CBUEN9CkfM5Gkt9GZMq%2FFdbPdE%3D&reserved=0, or unsubscribehttps://can01.safelinks.protection.outlook.com/?url=https%3A%2F%2Fgithub.com%2Fnotifications%2Funsubscribe-auth%2FAA3NYWPNMSOJVJUCQAX3EZTVTQKHNANCNFSM53HNEV2A&data=05%7C01%7Ctimothy.frasier%40smu.ca%7C83c1dbedcdda40b8161108da633c2988%7C060b02ae57754360abbae2e29cca6627%7C1%7C0%7C637931407282537665%7CUnknown%7CTWFpbGZsb3d8eyJWIjoiMC4wLjAwMDAiLCJQIjoiV2luMzIiLCJBTiI6Ik1haWwiLCJXVCI6Mn0%3D%7C3000%7C%7C%7C&sdata=%2BiL6j12S5JR1y2uQ%2FSQmRSjYO%2BwTuxPaZT%2BDHWCVTGU%3D&reserved=0. You are receiving this because you are subscribed to this thread.Message ID: @.***>
Hi Timothy,
I run the coancestry analysis for a dataset of 98 individuals and 7400 SNPs. The highest values of relatedness among individuals have been obtained for those belonging to a population with the lowest Fis coefficient. Almost every pairs of individuals of that population have a relatedness value between 0.15 and 0.17 (the maximun value was 0.17). The inbreeding estimates obtained by the function also agree with Fis. I have no idea about the reason of these inconsistent results. I understood that the higher values of inbreeding coefficient, the higher relatedness values would be obtained. Am I doing or understanding something wrong? Maybe I am ignoring some mathematical detail.
Thank you so much!
Lucía