tjhwangxiong / TCGAplot

A number of functions were generated to perform pan-cancer DEG analysis, correlation analysis between gene expression and TMB, MSI, TIME, and promoter methylation. Methods for visualization were provided in order to easily perform integrative pan-cancer multi-omics analysis.
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When tpm values are all zeros, the gene_TMB_radar function not working #20

Closed microbioin closed 3 weeks ago

microbioin commented 1 month ago

For this UGT1A9 gene, the tpm values in UVM cancer type is all 0. so the correlation calculation in gene_TMB_radar function will show "the standard deviation is zero" , and the radar chart will be broken. Hope to add a checking function. Thank you.

tjhwangxiong commented 1 month ago

可能是因为我们为了让R包整体大小小一点,tpm我们只保留了一位小数。

Department of Laboratory Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China Tel: +86 027-83665471        +86 13554663391

      ------------------ Original ------------------ From: @.>; Date:  Thu, Sep 19, 2024 10:54 AM To: @.>; Cc: @.***>; Subject:  [tjhwangxiong/TCGAplot] When tpm values are all zeros, the gene_TMB_radar function not working (Issue #20)

 

For this UGT1A9 gene, the tpm values in UVM cancer type is all 0. so the correlation calculation in gene_TMB_radar function will show "the standard deviation is zero" , and the radar chart will be broken. Hope to add a checking function. Thank you.

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microbioin commented 1 month ago

this may be the reason. I extract the tpm of all genes for all samples, about 1G. so huge. thank you,