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tkkarjal / magia

Automated brain PET analysis pipeline
https://doi.org/10.3389/fninf.2020.00003
MIT License
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Important: PET-template-based spatial normalization ('old normalize') problem #88

Closed tkkarjal closed 4 years ago

tkkarjal commented 4 years ago

Using [11C]raclopride data I noticed that the process of warping the standardized radioactivity template to an individual's mean-PET image is highly unstable. Two Magia-runs with identical settings can lead to dramatically different BP estimates (e.g. in putamen 4 vs. 1). On the other hand the warpings from the individual to the template work much more reliably.

The process needs to be changed. If PET-based spatial normalization is used, then the ROIs should not be warped from the MNI space to the individual space. Instead, the individual PET images should be warped to MNI space.

tkkarjal commented 4 years ago

I created a new branch for this

colddie commented 4 years ago

Is this problem solved?

tkkarjal commented 4 years ago

Yes, the problem has been solved. Thanks for asking.