tleonardi / nanocompore

RNA modifications detection from Nanopore dRNA-Seq data
https://nanocompore.rna.rocks
GNU General Public License v3.0
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Add an option to combine intensity and dwell pValue for parametric tests #83

Open a-slide opened 5 years ago

a-slide commented 5 years ago

For non parametric tests, Nanocompore performs 1 test or Dwell time and 1 test for intensity per position. I would be nice to combine both using the Hou's method

An alternative solution would be to implement a bivariate parametric or non-parametric test such as the Hotelling's T-squared distribution or a bivariate KS test => https://www.sciencedirect.com/science/article/pii/S0047259X03000794?via%3Dihub

a-slide commented 5 years ago

Or something like that: https://stats.stackexchange.com/questions/27288/two-dimensional-kolmogorov-smirnov One of the answers mentions a Python implementation