This is called persistent keepalives. When this option is enabled, a keepalive packet is sent to the server endpoint once every interval seconds. A sensible interval that works with a wide variety of firewalls is 25 seconds. Setting it to 0 turns the feature off, which is the default, since most users will not need this, and it makes WireGuard slightly more chatty.
https://www.wireguard.com/quickstart/#nat-and-firewall-traversal-persistence