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trvrb / flux

Integrating influenza antigenic dynamics with molecular evolution
http://bedford.io/papers/bedford-flux/
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Interference references #8

Closed trvrb closed 11 years ago

trvrb commented 11 years ago

The authors suggest that interference between clades could be due to CTL epitopes. While this is one plausible explanation, it could also be due to other forms of cross-reactive immunity such as broadly reactive anti-hemagglutinin antibodies (http://www.ncbi.nlm.nih.gov/pubmed/21878571, http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2860935/) or antibodies against internal proteins (http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3597515/).

trvrb commented 11 years ago

We have expanded this paragraph to encompasss broadly neutralizing anti-HA antibodies and antibodies to internal proteins and included the above references.