Just a couple of examples of stack size challenges in the game.
Stack size for rotten flesh is only 8 pieces, but the clerics in villages require stacks of rotten flesh well over 16 pieces, so you can't trade for items. We need to either adjust the pieces required to trade with the villagers or adjust the stack size for items to match.
The mixer recipes need to adjust as well, or the stack sizes need to be increased. For example, to create biomass using tomatoes and mulch, it takes a stack of 32 tomatoes and 1 mulch, but the maximum stack size for tomatoes is 16. This prevents the recipe from working.
There may be more examples that need rationalization to ensure all things are working, but it will be difficult to determine all of the issues.
Just a couple of examples of stack size challenges in the game.