Same issue observed in call-sSV. Processing large WGS samples with a single-thread takes more than a week. Optimizing CPU allocation for Manta could drastically reduce compute costs. We've done benchmarking in call-SNV and also this paper reports similar observations - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10976732/ (see Multi-thread computing test for SV callers)
Same issue observed in call-sSV. Processing large WGS samples with a single-thread takes more than a week. Optimizing CPU allocation for Manta could drastically reduce compute costs. We've done benchmarking in call-SNV and also this paper reports similar observations - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10976732/ (see Multi-thread computing test for SV callers)