umb-oconnorgroup / plasmodium_snp_call_pipeline_wdl

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Missing VQSLOD field in the generated VCF file. #1

Open bguo068 opened 3 years ago

bguo068 commented 3 years ago

GATK uses two different approaches for site-level variant filtration: 1) Hard filtering 2) VQSR. See here

Currently, the pipeline uses hard filtering only but VQSLOD is generated by VQSR method (VariantRecalibrator and ApplyVQSR). There should be an option to choose which method for variant filtering.

(VQSR method generated VQSLOD is needed by dEploid deconvolution.)