umccr / umccrise

:snake: DRAGEN Tumor/Normal workflow post-processing
https://umccr.github.io/umccrise/
MIT License
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SNVs: Update CSQ metadata line based on PCGR/VEP usage #101

Closed pdiakumis closed 2 years ago

pdiakumis commented 2 years ago

The CSQ metadata line in the somatic VCF can get out of sync with the VEP options specified in PCGR, which can be confusing for downstream users. See https://github.com/umccr/vcf_stuff/blob/110f115d7c541c06209e0acf4ff3dbc36874e651/vcf_stuff/filtering/annotate_somatic_vcf.smk#L402 and the attached diff. We should probably read that directly from the PCGR output file instead of hard-coding it.

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