But - in my opinion - before showing any 3D structure it would be much more helpful to show a domain diagram of the protein, so that the user can see the main functional units and the active site. Such functionality is readily available at InterPro: http://www.ebi.ac.uk/interpro/protein/P53350
For anyone interested in enzyme engineering, targeting an enzyme with inhibitors, exploring its mechanism, or modeling its activity, a vital piece of information is where in the protein the active site residues are located. This information is often present in UniProt and also often shown in the output from DASty, e.g.: http://www.ebi.ac.uk/dasty/client/index.html?q=P53350 - although the DASty output is somewhat lengthy and takes a long time to load.
Showing domains and vital residues in a compact diagram is achieved nicely by the NCBI's Conserved Domain Database (CDD) site: http://www.ncbi.nlm.nih.gov/Structure/cdd/wrpsb.cgi?INPUT_TYPE=live&SEQUENCE=P53350
(although I don't expect the EBI to use display from the NCBI directly).
In my opinion such a diagram is so helpful that it should have a place on the 'front page' of any enzyme report.
From a user's feedback:
But - in my opinion - before showing any 3D structure it would be much more helpful to show a domain diagram of the protein, so that the user can see the main functional units and the active site. Such functionality is readily available at InterPro: http://www.ebi.ac.uk/interpro/protein/P53350
For anyone interested in enzyme engineering, targeting an enzyme with inhibitors, exploring its mechanism, or modeling its activity, a vital piece of information is where in the protein the active site residues are located. This information is often present in UniProt and also often shown in the output from DASty, e.g.: http://www.ebi.ac.uk/dasty/client/index.html?q=P53350 - although the DASty output is somewhat lengthy and takes a long time to load. Showing domains and vital residues in a compact diagram is achieved nicely by the NCBI's Conserved Domain Database (CDD) site: http://www.ncbi.nlm.nih.gov/Structure/cdd/wrpsb.cgi?INPUT_TYPE=live&SEQUENCE=P53350 (although I don't expect the EBI to use display from the NCBI directly). In my opinion such a diagram is so helpful that it should have a place on the 'front page' of any enzyme report.