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uubram / RTCR

A pipeline for complete and accurate recovery of TCR repertoires from high throughput sequencing data.
GNU General Public License v3.0
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Question about rnaseq data #21

Open GuidoLeoni opened 2 years ago

GuidoLeoni commented 2 years ago

Is it possible to utilize your tool for the detection of TCRb in bulk tumor rnaseq data(ie without enrichment of tcrs)?

In case, do you think that it is necessary to change any parameter respect the canonical settings?

thank you Guido

uubram commented 2 years ago

I think your scenario is effectively a 'low read count' situation (i.e. low read count for TCRs). It should be possible to use RTCR without any changes to its settings.

Best wishes, Bram