Single-Cell Proteomics - Githubissues

vdemichev / DiaNN

DIA-NN - a universal automated software suite for DIA proteomics data analysis.

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Single-Cell Proteomics #957

Open zhangdong360 opened 4 months ago

zhangdong360 commented 4 months ago

Hello，

I am currently conducting single-cell proteomics experiments because our sample signals are much weaker compared to conventional DIA. I was wondering if DIA-NN has a similar way to adjust signal-to-noise ratio to improve results? The results for Precursors.Identified and Proteins.Identified are currently showing as 0, and we are unable to obtain them through DIA-NN.

Kind regards, Dong

vdemichev commented 4 months ago

Hi Dong,

Makes sense to try analysing with a spectral library. If does not work - likely something wrong with the samples.

Best, Vadim