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How are DPP4 interactions classified? #8

Open dnjst opened 1 year ago

dnjst commented 1 year ago

Dear developers,

Congratulations on cellphonedb v5! I love the fact that this version includes the "classification" and "directionality" metadata.

I was wondering, in the interactions where DPP4 is listed as a receptor - does this protein act as a receptor for all of these ligands? Or is it modifying circulating chemokines by cleaving them to activate or inhibit them? Because currently it is classified as "Ligand-Receptor".I don't know the cell biology well enough to interpret these results - Thanks.

datasome commented 1 year ago

Dear dnjst,

Thank you for your inquiry and my apologies for the delayed reply. We're currently somewhat short on curation capacity but to try and answer your question, https://febs.onlinelibrary.wiley.com/doi/10.1111/j.1742-4658.2011.08051.x would suggest that DPP4 does indeed CCL11 to activate/inhibit it. It may just be that CellphoneDB curators have chosen not to use a special 'directionality' value for this and just stuck to Ligand-Receptor. If I manage to find out more, I will let you know.

Best,

Robert.