search

vineetsk1 / Switch-Strategies

Implementations of the strategies for Eternabot switches.
0 stars 2 forks source link

[Strategy Market] [Switch] JL’s microRNA fish hook 1 #3

Open vineetsk1 opened 9 years ago

vineetsk1 commented 9 years ago

Original Author: Eli Fisker

Original Link: https://getsatisfaction.com/eternagame/topics/-strategy-market-switch-jl-s-microrna-fish-hook-1

Intro

This strategy is courtesy to jandersonlee and based on his superior round 1 microRNA design strategy, that ended hitting through among the majority of the winners in the following round too.

MicroRNA catcherpng

Strategy for microRNA labs

I wish to reward when there are a series of dangling single bases in the unbound state, that are complementary to the early part of the microRNA.

Give +2 for each complementary base in the dangle that are capable of pairing up with the first 8 bases of the MicroRNA (counting from 5’ end)

Give -1 if one of these bases are not the strongest complement.

General MicroRNA dangle ranking

Best position of the dangle ranged in order of best to worst:

MicroRNA complementary series of bases is in the 3’ end of the RNA design in an dangling tail - Give full points of the sum of the above

MicroRNA complementary series of bases is in gap bases - stretch between elements - Give 3/4 points of the sum

5’ end of the RNA design in a dangling tail - Give 1/2 of the sum

Multiloop ring bases - Give 1/3 points of the sum

Give 1/4 of the points for the design that has a dangle that aims for anything else than the first 8 bases of the microRNA.

No dangle - no points :)

Background articles

MicroRNA welcoming dangling tail

Imagining the microRNA labs

vineetsk1 commented 9 years ago

Implemented with 58 lines of code.