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Phase II Lab/Experiment(s) Hosting\Rehosting Request for Neuron Simulation Virtual Lab AU #729

Open amritamindbrain opened 3 years ago

amritamindbrain commented 3 years ago

  1. Lab Name: Neuron Simulation Virtual Lab

  2. List of Experiments and Repositories:

  1. Course Alignment: (1) UG in Biotechnology/Microbiology/Bioinformatics/Biomedical Science (2) PG in Biotechnology/Microbiology/Bioinformatics/Biomedical Science (3) B.Tech./ B.E in Biotechnology

  2. Target Audience: (1) UG (2) PG (3) PhD/Research Scholars (4) B Tech (5) M Tech

pavanchow commented 3 years ago

@amritamindbrain Could you please provide the Broad Area, Introduction, and Objective of the Lab?

amritamindbrain commented 3 years ago

Broad Area : Biotechnology and Biomedical Engineering

Introduction :

This lab models a section of excitable neuronal membrane using the Hodgkin-Huxley equations. This lab focuses on understanding basic principles of resting potentials and describe mathematical models for studying resting potential of neurons. Experiments deigned in this lab explores in-depth about modelling of action potentials, role of potassium and sodium ion channels in neurons and describe how these ion channels affect the spiking patterns and how the gating properties regulate channel behavior firing patterns of different neurons. Students can expand their laboratory skillset by understanding the behavior of a nerve cell under different physiological conditions by studying the varying firing patterns at specific time period. The laboratory course can be further utilized as a self-learning or reference material for life science students.

Objective of the Lab :

  1. Understand Hodgkin-Huxley equations and its parameters in details and to model resting and action potentials, voltage and current clamp, pharmacological effects of drugs that block specific channels.

  2. To visualize how resting ion channels maintain the resting potential and introduction of mathematical models used for studying this mechanism.

  3. To study the importance of ion channels in neuronal signal propagation. To explore the importance of K+ channels and to study how it serves as a delayed rectifier and to understand the dynamic properties of Na+ channels on neural signaling.

  4. To provide overview of capacitance and conductance properties of a nerve cell in action potential generation and propagation.

  5. To study the pattern of firing patterns using channel specific drugs at varying concentrations.

pavanchow commented 3 years ago

@amritamindbrain Experiments are hosted using tags, so whatever is in the tag is hosted. Could you please create new tags with updated content? Hosted Neuron Simulation Virtual Lab with mentioned tags URL of Lab: https://nsvl-au.vlabs.ac.in

Please check and approve

amritamindbrain commented 3 years ago

@pavanchow

Experiment content is not mapped as in the main branch. Content hosted in the main branch are as follows. Neuron Simulation Virtual Lab

  1. Modeling resting potentials in Neurons https://virtual-labs.github.io/exp-modeling-resting-potentials-au/

  2. Modeling action potentials https://virtual-labs.github.io/exp-modeling-action-potentials-au/

  3. Modeling the delayed rectifier Potassium channels https://virtual-labs.github.io/exp-potassium-channels-au/

  4. Modeling the sodium ion channel and its effects on neural signaling https://virtual-labs.github.io/exp-sodium-ion-channel-au/index.html

  5. Current Clamp protocol https://virtual-labs.github.io/exp-current-clamp-protocol-au/

  6. Voltage Clamp Protocol https://virtual-labs.github.io/exp-voltage-clamp-protocol-au/

  7. Understanding first spike latency-current relationship https://virtual-labs.github.io/exp-spike-latency-current-relationship-au/

  8. Understanding Frequency-Current relationship https://virtual-labs.github.io/exp-frequency-current-relationship-au/

  9. Voltage-Current (VI) plot https://virtual-labs.github.io/exp-voltage-current-plot-au/

  10. Effects of pharmacological blockers on action https://virtual-labs.github.io/exp-pharmacological-blockers-au/index.html

pavanchow commented 3 years ago

@amritamindbrain Please create new tags with the updated content.

amritamindbrain commented 3 years ago

@pavanchow

New tags has been created. Please host these experiments.

  1. Lab Name: Neuron Simulation Virtual Lab

  2. List of Experiments and Repositories:

pavanchow commented 3 years ago

@amritamindbrain Hosted Neuron Simulation Virtual Lab with mentioned tags URL of Lab: https://nsvl-au.vlabs.ac.in

Please check and approve

amritamindbrain commented 3 years ago

@pavanchow

New tags has been created. Please re-host these experiments.

Lab Name: Neuron Simulation Virtual Lab

List of Experiments and Repositories:

Modeling resting potentials in Neurons https://github.com/virtual-labs/exp-modeling-resting-potentials-au v1.0.2

Modeling action potentials https://github.com/virtual-labs/exp-modeling-action-potentials-au v1.0.2

Modeling the delayed rectifier Potassium channels https://github.com/virtual-labs/exp-potassium-channels-au v1.0.2

Modeling the sodium ion channel and its effects on neural signaling https://github.com/virtual-labs/exp-sodium-ion-channel-au v1.0.2

Current Clamp protocol https://github.com/virtual-labs/exp-current-clamp-protocol-au v1.0.2

Voltage Clamp Protocol https://github.com/virtual-labs/exp-voltage-clamp-protocol-au v1.0.2

Understanding first spike latency-current relationship https://github.com/virtual-labs/exp-spike-latency-current-relationship-au v1.0.2

Understanding Frequency-Current relationship https://github.com/virtual-labs/exp-frequency-current-relationship-au v1.0.2

Voltage-Current (VI) plot https://github.com/virtual-labs/exp-voltage-current-plot-au v1.0.2

Effects of pharmacological blockers on action https://github.com/virtual-labs/exp-pharmacological-blockers-au v1.0.2

pavanchow commented 3 years ago

@amritamindbrain Hosted Neuron Simulation Virtual Lab with mentioned tags(v1.0.2) URL of Lab: https://nsvl-au.vlabs.ac.in

Please check and approve

amritamindbrain commented 3 years ago

@pavanchow

issues with 2 experiments. new tags created for those experiments. rest everything is fine.

Modeling the delayed rectifier Potassium channels https://github.com/virtual-labs/exp-potassium-channels-au v1.0.3

Effects of pharmacological blockers on action https://github.com/virtual-labs/exp-pharmacological-blockers-au v1.0.3

pavanchow commented 3 years ago

@amritamindbrain Hosted Neuron Simulation Virtual Lab with mentioned experiments. URL of Lab: https://nsvl-au.vlabs.ac.in

Please check and approve

amritamindbrain commented 3 years ago

@pavanchow

issues with 1 experiment. new tag created for the experiment. rest everything is fine.

Modeling the delayed rectifier Potassium channels https://github.com/virtual-labs/exp-potassium-channels-au v1.0.4

pavanchow commented 3 years ago

@amritamindbrain Hosted Neuron Simulation Virtual Lab with Modeling the delayed rectifier Potassium channels experiment. URL of Lab: https://nsvl-au.vlabs.ac.in

Please check and approve

amritamindbrain commented 3 years ago

@pavanchow

verified.

ravikiran2020 commented 5 months ago

Rehosting the lab with Bug Report and Rating Feature

ravikiran2020 commented 4 weeks ago

Re-hosting the lab