A Pilot Study Exploring the Association of Entacapone, Gut Microbiota, and the Subsequent Side Effects in Patients With Parkinson's Disease

[lwaldron]

A Pilot Study Exploring the Association of Entacapone, Gut Microbiota, and the Subsequent Side Effects in Patients With Parkinson's Disease https://pubmed.ncbi.nlm.nih.gov/35463646/

[Faith-Adegoke]

Hello. I would like to curate this paper; can it be assigned to me? Thank you

[Msjulieozi]

Kindly assign me to curate this paper @SvetlanaUP Thank you

[SvetlanaUP]

Assigned to @Faith-Adegoke

[Faith-Adegoke]

Assigned to @Faith-Adegoke

Thank you!

[fiddyhamma]

Hello @Faith-Adegoke do you need assistance with this curation? I'll be happy to help 😊

[fiddyhamma]

Hello @SvetlanaUP I searched this article on BugSigdb and I noticed it is an incomplete study (study 952). Can I assist @Faith-Adegoke with this if I don't get a response by Thursday?

[SvetlanaUP]

@fiddyhamma please be patient and give some time to @Faith-Adegoke to get back to your message. Thank you.

[Analyst-Joan]

hello @Faith-Adegoke, Trust you're fine?

This study at Study_952, is still listed under "Studies that have no Experiments"

If you need support/help with it, do let me know.

Sending you my best wishes.

[Faith-Adegoke]

Hello @SvetlanaUP I searched this article on BugSigdb and I noticed it is an incomplete study (study 952). Can I assist @Faith-Adegoke with this if I don't get a response by Thursday?

Hi @fiddyhamma, you can go ahead with the curation. Sorry for the late response.

[SvetlanaUP]

Assigned to @fiddyhamma

[fiddyhamma]

Thank you so much @Faith-Adegoke

[fiddyhamma]

Hello @SvetlanaUP this curation is complete and I'd love a review https://bugsigdb.org/Study_952

[Scholarpat]

Hi @SvetlanaUP,

These are the changes I've made to this curation:

• Changed the study design from case-control to cross-sectional. In this study, subjects from both groups were Parkinson's disease (PD) patients. There is no healthy control group.

• Group 1 definition: Changed from "Entacapone, one of the most common drugs distributed among patients with Parkinson’s disease, is a peripherally acting catechol-O-methyltransferase (COMT) inhibitor that is used in addition to levodopa to control symptoms" to "Parkinson's disease (PD) patients treated with both levodopa and Entacapone, a peripherally acting catechol-O-methyltransferase (COMT) inhibitor that is used in addition to levodopa to control symptoms."

• Source Description: Changed from "ASVs that significantly differed in abundance before and after the treatment of entacapone. 108 ASVs were identified as significantly different after the treatment of entacapone. 3 ASVs that were not assigned taxonomy to the genus level had a decrease in abundance. They were removed for plotting purposes. Genus and phylum level classification of the significant ASVs are provided in the plot. Genus in bold are unique to our study when compared with Weis et al. (2019)." to "Genera significantly different in abundance in Parkinson's disease patients treated with levodopa only (PD_L) versus Parkinson's disease (PD) patients treated with both levodopa and Entacapone (PD_LE)."

Every other data looks okay to me. Well done, @fiddyhamma. 👍

[SvetlanaUP]

https://bugsigdb.org/Study_952 reviewed.