I noticed that SAIGE-GENE+ is perfectly suited for large-scale cohorts such as UKB. Now I wonder if it works for much smaller cohorts, like 300 cases vs. 300 controls.
Also, I received an error: "ERROR! The first variance component parameter estimate is 0" when I ran Step 1 on about 1,000 samples. Does this have anything to do with the small sample size?
Is there any guidance for the recommended sample size for the application of SAIGE-GENE+ to continuous and binary traits?
Hi,
Thanks for your great tool!
I noticed that SAIGE-GENE+ is perfectly suited for large-scale cohorts such as UKB. Now I wonder if it works for much smaller cohorts, like 300 cases vs. 300 controls.
Also, I received an error: "ERROR! The first variance component parameter estimate is 0" when I ran Step 1 on about 1,000 samples. Does this have anything to do with the small sample size?
Is there any guidance for the recommended sample size for the application of SAIGE-GENE+ to continuous and binary traits?
Thanks in advance!
Best regards, Jixin