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welch-lab / liger

R package for integrating and analyzing multiple single-cell datasets
GNU General Public License v3.0
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,is this integration method suitable for data from different species on different platforms? #135

Closed zhurenaibobi closed 4 years ago

zhurenaibobi commented 4 years ago

Dear all, I have a question,is this integration method suitable for data from different species on different platforms? Because my data comes from different species, one is a mouse(10X) and one is a dog(split-seq). They are the same tissues：Olfactory bulb . Thanks in advance.

yours, limanman

jw156605 commented 4 years ago

Yes, this is possible. In the LIGER paper, we used LIGER to integrate single-cell RNA-seq from mouse substantia nigra with single-nucleus RNA-seq from human substantia nigra. Obviously, this experimental design is less desirable than one in which data from both species come from the same platform.