wwood / CoverM

Read coverage calculator for metagenomics
GNU General Public License v3.0
273 stars 30 forks source link

replacing FastANI with skani for faster computations for the cluster command #155

Open jianshu93 opened 1 year ago

jianshu93 commented 1 year ago

Hello Ben,

This is Jianshu again, recently our team here at Georgia tech review a very interesting paper (https://www.biorxiv.org/content/10.1101/2023.01.18.524587v1), the tool is called skani, which further accelerate FastANI by 20 times via even faster seeding and chaining technique and also FracMinHash (https://www.biorxiv.org/content/10.1101/2022.01.11.475870v3.abstract). More importantly it is fully parallelized and written in Rust. I tried and benchmarked it against blast based ani an also orthoANI (as in the paper) and it is just as good as FastANI while being 20X faster. I believe integrating it into coverm cluster will be very easy since the code is very clear to me.

Thanks,

Jianshu