Can I used for tumor-only bulk mRNA-seq? - Githubissues

wwylab / TmS

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Can I used for tumor-only bulk mRNA-seq? #2

Open kyle-lk opened 1 year ago

kyle-lk commented 1 year ago

Can I used for tumor-only bulk mRNA-seq?

jiyunmaths commented 1 year ago

Hi @kyle-lk TmS calculation needs normal sample as the reference for bulk mRNA-seq deconvolution using DeMixT (https://github.com/wwylab/DeMixT). If you do not have RNA-seq data for the normal, we recommend you to use the normal sample data from TCGA or GTEx (https://gtexportal.org/home/) which are sequenced from the same tissue as your tumor RNA-seq data. Thanks.