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xia-lab / MetaboAnalystR

R package for MetaboAnalyst
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Normalization using internal standard mixture #30

Closed XiaoyangSu closed 5 years ago

XiaoyangSu commented 5 years ago

I see that the normalization can be done to a specified feature, such as an internal standard. If we have a mixture of internal standards, can we normalize each sample to this mixture to maximize accuracy?

jsychong commented 5 years ago

Hi, it makes sense to do that - by your mixture of internal standards do you mean having several internal standards with different RT spanning your entire analysis time? If so, MetaboAnalystR does not support such normalization, but you should be able to do this in R.

XiaoyangSu commented 5 years ago

Yes. We have a mixture of internal standards to cover multiple metabolite classes and the whole chromatography time domain. Is there a plan to support it in MetaboAnalystR? Thanks!

jsychong commented 5 years ago

Not at this point but we will now add it to our considerations for future upgrades, cheers!