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xmuhuanglab / eNet

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if this software is suitable for bulk tissue ATAC-seq and RNA-seq #7

Open TaoHJiang opened 1 year ago

TaoHJiang commented 1 year ago

Thank you for providing very useful software. I wonder if this software is suitable for bulk tissue ATAC-seq and RNA-seq.

dhoneyi commented 1 year ago

Hi,

Thanks for your interest. Using eNet analysis of bulk ATAC-seq and bulk RNA-seq is theoretically applicable, but due to the limited number of bulk samples, the calculation of gene-enhancer correlations and enhancer-enhancer interactions will be affected.

Best wishes, Danni

TaoHJiang commented 1 year ago

Hi, Thank you for your reply. And how many samples do you think it would take to do that?