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xuranw / MuSiC

Multi-subject Single Cell Deconvolution
https://github.com/xuranw/MuSiC
GNU General Public License v3.0
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Memory requirements #129

Open gevro opened 3 months ago

gevro commented 3 months ago

Hi, MuSiC is crashing with a single-cell reference of ~120k cells and 36 bulk samples due to memory limitations, even with 128 Gb RAM.

What are the memory requirements?

Thanks

gevro commented 3 months ago

Note, it seems that high memory and time requirements are being caused specifically by the # of cells in the single-cell reference. I can analyze with up up to ~500 cells, but anything more than that takes > 30 minutes and eventually crashes due to out of memory even with 128 Gb ram.

Is there something I am missing in terms of how to run this?