Add a function that displays the degree of agreement in instrument associations

yoonsucho / CAMERA

Mendelian Randomization approach using Cross Ancestral Model

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Add a function that displays the degree of agreement in instrument associations #2

Open explodecomputer opened 3 years ago

explodecomputer commented 3 years ago

Add a function that displays the degree of agreement in instrument associations between populations - if they really disagree then issue a warning that it might be unreliable

Could also check if the units are the same?
If the units are different then try to estimate the variance of the trait, and then normalise the beta and se. e.g. b = b/sqrt(trait_var); se = se/sqrt(trait_var) - this is already implemented in TwoSampleMR::standardise_units()

Note will need to do the same for the outcomes

yoonsucho commented 3 years ago

New function instrument_check() is added

unit info is missing? -> standardised regardless
In which case the function should be applied?; after extract_outcome_data

yoonsucho commented 3 years ago

The users can choose an option to normalise the beta and se when the units are different: extract_outcome_data(exp=x$instrument_raw, standardise=FALSE, p_exp=1)

yoonsucho commented 3 years ago

Employing POPCORN to present genetic correlation of the phenotypes?