According to recently published paper (e.g., Belbasi et.al.,2023, bioinformatics and Blanca et.al., 2022, JCB), Poisson approximation can be avoided to achieve even accurate point mutation rate estimation. Instead, Binomial model derived mutation rate can be more accurate for divergent genomes.
Please review and merge if all tests passed. I have all tests passed at my end.
According to recently published paper (e.g., Belbasi et.al.,2023, bioinformatics and Blanca et.al., 2022, JCB), Poisson approximation can be avoided to achieve even accurate point mutation rate estimation. Instead, Binomial model derived mutation rate can be more accurate for divergent genomes. Please review and merge if all tests passed. I have all tests passed at my end.
Many Thanks,
Jianshu